After Abraham's obedience at the Akedah — the binding of Isaac on a mountain 'in the land of vision' (Moriah) — the angel of the LORD swore by God Himself: 'Because thou hast done this thing... in thy seed shall all the nations of the earth be blessed, because thou hast obeyed my voice' (Genesis 22:16–18). Jewish and Christian tradition alike identified Moriah with the Temple Mount at Jerusalem (2 Chronicles 3:1).
St. Paul stakes the argument of Galatians on the grammar of the promise: 'To Abraham were the promises made and to his seed. He saith not, And to his seeds, as of many: but as of one, And to thy seed, which is Christ' (Galatians 3:16). In Christ, descended from Abraham (Matthew 1:1), the nations of the earth — the Gentiles — entered the blessing of Abraham through faith.
The Fathers saw in the scene itself a wordless prophecy: the beloved son carrying the wood of his own sacrifice up the hill, and the father receiving him back alive on the third day (Genesis 22:4; Hebrews 11:17–19) — enacted a few hundred meters from where Christ would carry His Cross.