Anne (Spanish Ana Lobera) was born on November 25, 1545 at Medina del Campo in Castile to the noble Castilian Lobera family. In 1570, at the age of 25, Anne entered the Discalced Carmelite Monastery of San José at Ávila under the personal direction of St. Teresa of Ávila (see her existing entry) — becoming one of Teresa's principal disciples.
Teresa famously called Anne 'my daughter and my crown'. Anne served as Teresa's personal secretary and travelling companion during Teresa's Spanish Discalced Carmelite foundations (1570s–1580s), accompanying Teresa in the founding of multiple Discalced Carmelite Monasteries.
In 1582, on the death of Teresa (October 4, 1582), Anne became prioress at Granada — continuing the Discalced Carmelite reform under the 'Teresian' direction (against the competing 'Doria' direction of Fr. Nicholas Doria, the Discalced Carmelite superior of the 1580s–1590s who attempted to alter the Teresian constitutions).
In 1604, at the invitation of Cardinal Pierre de Bérulle (see his entry), Anne led a delegation of Discalced Carmelites to Paris — establishing the first Discalced Carmelite Monastery in France (the famous Carmel of the Incarnation on the Rue Denfert, Paris, the formation-house of Bl. Marie of the Incarnation Acarie — see her existing entry).
In 1607, Anne moved on to Brussels in the Spanish Netherlands to establish the Discalced Carmelite Monastery of Brussels — producing the institutional foundation of the Belgian and Dutch Discalced Carmelite tradition.
She died at Brussels on March 4, 1621 at the age of 75.