John Francis Regis was born on January 31, 1597 at Fontcouverte in Provence to the noble Provençal Regis family. In 1616 (at 19), John Francis entered the Society of Jesus at Toulouse.
Ordained priest in 1630, John Francis undertook the Jesuit missionary vocation to the Huguenot-and-Catholic mixed highland Massif Central region of southern France — the Cévennes Mountains and the Vivarais region.
For the 10 years (1630–1640), John Francis travelled across the Cévennes and Vivarais highlands on foot, preaching to both Catholic and Huguenot villagers. He famously reconverted tens of thousands of lapsed Catholic villagers.
John Francis undertook the social ministry: founding multiple Le Puy-en-Velay lace-making cooperatives that provided unemployed women with work; establishing orphanages and homes for fallen women.
On December 30, 1640, John Francis arrived at the village of La Louvesc in the middle of a snowstorm to preach at the Christmas mission. He died the next morning (December 31, 1640) of pneumonia at the age of 43.

