John Southworth was born in 1592 at Samlesbury in Lancashire to the noble Southworth recusant Catholic family. Educated at the continental English College at Douai, John was ordained Catholic priest in 1618.
John returned to England as a secular Catholic recusant priest — serving in Lancashire and London for the 36 years (1618–1654).
During the Puritan Commonwealth under Oliver Cromwell (1653–1659), John undertook the systematic ministry to the plague victims of London during the plague of 1654.
Arrested in 1654 on the old Catholic-priesthood-treason charges, John was condemned to death.
On June 28, 1654, John was hanged, drawn, and quartered at Tyburn — at the age of 62.
His body was purchased by the Spanish Ambassador and translated to the English College at Douai. In 1930, following the rediscovery of his body during the excavation of the former Douai College (by Bishop Michael Hughes-Games), John's body was translated to Westminster Cathedral in London — where it rests in the Chapel of St. George and the English Martyrs.
Canonized on October 25, 1970 by Pope St. Paul VI.

