Nikon was born around 1352 at Yuriev-Polsky. He entered the Holy Trinity-Sergius Lavra under the personal spiritual direction of St. Sergius of Radonezh (see his existing entry).
Upon St. Sergius's death on September 25, 1392, Nikon was elected second abbot of the Holy Trinity-Sergius Lavra — taking up the governance of the mother-monastery of the Sergian tradition.
Nikon's thirty-four-year abbacy (1392–1426) was devoted to the institutional consolidation of the Sergian tradition and the rebuilding of the Lavra after the catastrophic 1408 Tatar sack of the monastery by the Tatar Khan Edigu.
Nikon commissioned the rebuilding of the Trinity Cathedral (1422–1423) — the famous stone cathedral that would house the Trinity Icon of St. Andrei Rublev (see the existing entry for Andrei Rublev). Rublev's famous Trinity Icon was painted around 1425–1427 for the new Trinity Cathedral under Nikon's commission — the Nikon-Rublev collaboration producing the most famous single icon of the Russian Catholic-Orthodox tradition.
Nikon died at the Holy Trinity-Sergius Lavra on November 17, 1426.

