Carlo Antonio Divini was born at San Severino in the Marche of Ancona, was orphaned at five, was raised by an uncle who treated him harshly, and entered the Reformed Franciscans at seventeen in 1670 — taking the name Pacifico. He was ordained priest in 1678, served as professor of philosophy at the Recanati convent for several years, and then for twenty years (1679–99) as a wandering preacher and confessor in the Marche and southern Romagna.
Around 1690, in his late thirties, he was struck progressively by a series of severe physical afflictions: progressive deafness, then blindness, then severe ulcerated leg sores that confined him to a wheelchair-like cot, and ultimately a complete paralysis of his arms and legs. He spent the remaining thirty years of his life — over half his religious life — in this state of progressive bodily devastation, while remaining the principal spiritual director of his region. Hundreds of penitents travelled to his cell at the San Severino convent each week; he wrote his counsels on a slate held against his chest, the responses dictated by friars who pressed his hand to indicate yes or no.
He died at the San Severino convent on September 24, 1721. Canonized 1839. He is one of the principal saints of the Marche pilgrim circuit between Loreto and Camerino.