William was born around 1085 in Liège, Lotharingia, to a noble Lotharingian family. Educated at the cathedral school of Reims and at the Benedictine Abbey of Saint-Nicaise at Reims, he became a Benedictine monk around 1113.
In 1119 he was elected Abbot of the Benedictine Abbey of Saint-Thierry near Reims — taking up the governance of the important medieval Champenois monastic community.
Around 1118 he first met St. Bernard of Clairvaux — and the intense personal friendship and theological-spiritual collaboration between the two Catholic spiritual masters became one of the principal friendships of the High Medieval Catholic spiritual tradition. William desired to enter Bernard's Cistercian community at Clairvaux, but Bernard insisted he should remain in the Benedictine abbacy of Saint-Thierry — to be a reforming voice for the broader Benedictine tradition.
In 1135, after sixteen years of Benedictine abbacy and repeated personal desire, William finally laid down the Saint-Thierry abbacy and entered the Cistercian Abbey of Signy in the Ardennes as a simple Cistercian monk — one of the few cases in medieval Western Catholic history of a sitting abbot voluntarily resigning to enter a stricter monastic community as a simple monk.
He spent the last thirteen years of his life (1135–1148) at Signy in Cistercian-monastic simplicity, composing his principal theological-mystical works. He died at Signy on September 8, 1148.
His principal theological-mystical works include: the Epistola Aurea (Golden Epistle / Letter to the Brothers of Mont-Dieu) — addressed to the Carthusian community of Mont-Dieu, one of the principal medieval Catholic spiritual-mystical treatises and the classic Western articulation of the three-stages spiritual ascent (animal, rational, spiritual); the De Natura et Dignitate Amoris (On the Nature and Dignity of Love), one of the principal medieval Western Catholic treatises on love; the De Contemplando Deo (On Contemplating God) and the Speculum Fidei (Mirror of Faith); Latin translations of the Greek Fathers (he translated portions of St. Gregory of Nyssa's De Hominis Opificio into Latin, one of the rare Greek-Patristic translation efforts of the High Medieval Latin West).
He also composed the disputation Contra Petrum Abaelardum (Against Peter Abelard) — his principal contribution to the famous Bernard-Abelard theological controversy of the 1140s.

