When the relics of St. Andrew the Apostle were translated from Constantinople to Amalfi in 1208 — at the end of the Fourth Crusade — they were placed in the crypt of the new cathedral being built for them. From at least 1304 (the earliest documented year) the same phenomenon noted at the tomb of St. Nicholas at Bari began at the tomb of Andrew: a clear, fragrant, watery liquid — also called 'manna' — began seeping from the bones.
The Manna of St. Andrew at Amalfi has been collected periodically through the centuries by the cathedral chapter, with notable major productions in 1304, 1306, 1308, 1322, 1359, 1387, 1411, 1457, 1485, and approximately seventeen times since the 17th century. The exudations seem to occur most reliably in winter and spring; the Saturdays of June 1 each year include a procession in which the year's collection is presented. The cathedral was visited by Pope Benedict XVI in 2008.